Molecular

Welcome to the PAHdb Molecular Modeling Site.  The aim of this web site is to serve as an online gallery of the latest in the 3-dimensional modeling of the phenylalanine hydroxylase enzyme (EC 1.14.16.1) and to map mutations to the affected region of the protein. Included on this site are high-resolution still and animated representations of the protein and the active site.

Stills

• NORMAL FORM
  • Full-length views
    • Figure 1 Structure of the phenylalanine hydroxylase full-length model
    • Figure 2 Ribbon diagram representations of the PheOHCterm and TyrOHCterm tetramers
    • Figure 3 The domains of the phenylalanine hydroxylase full-length model
    • Figure 4 C-alpha trace of one monomer of a full-length model of phenylalanine hydroxylase
  • Active site views
    • Figure 5 Close-up of the active site surrounding the catalytic iron
    • Figure 6 A view of seven of the residues lining the active site that cause PKU/HPA (another view)
• MUTATED FORM
  Close-ups of several mutations including hydrogen bonding
  • Figure 7 E76 mutation
  • Figure 8 R15 mutation
  • Figure 9 R252 mutation
  • Figure 10 R261 mutation
  • Figure 11 R297 mutation
  • Figure 12 Q304 mutation
  • Figure 13 Y377 mutation
  • Figure 14 R408 mutation

Animations

• Animation Phenylalanine hydroxylase enzyme

PAHdb Molecular Modeling data is maintained by Raymond Stevens (http://stevens.scripps.edu), Heidi Erlandsen, and C.R. Scriver.